Biochemical Characteristics of Caspases-3, -6, -7, and -8

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1 Aims: Our main objective was to analyze individual determinants that lead middle-2 aged women to seek medical care for UI. 3 Methods: Observational longitudinal study among GAZEL cohort participants: 2640 4 women aged 50-62 completed a self-administered questionnaire at baseline. Eight 5 years later (2008) 2273 (86%) responded to a follow-up questionnaire. Seeking care 6 for UI was defined as...

Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8.

Subsite interactions are considered to define the stringent specificity of proteases for their natural substrates. To probe this issue in the proteolytic pathways leading to apoptosis we have examined the P(4), P(1) and P(1)' subsite preferences of human caspases 1, 3, 6, 7 and 8, using internally quenched fluorescent peptide substrates containing o-aminobenzoyl (also known as anthranilic acid)...

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27 A 3,204 bp full-length cDNA of bovine NALP9 was cloned and its genomic organisation was 28 analyzed. The 2,988 bp open reading frame covers 9 exons and encodes a deduced protein of 996 29 amino acids containing Pyrin, Nacht and leucine-rich repeat domains like the human NALP gene 30 family members. Mapping with the WGRH5000 panel and fluorescence in situ hybridisation 31 assigned NALP9 in cl...

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